Goodnatured fun if you're south of the river
Yes, VoHo is the new scene, but the Two Brewers is a solid, friendly, fun night out and has been around like, for ever. For those like me (ahem) who remember it when it was a dubious local dive (though still fun, even then..) with blacked-out windows and a sidestreet entrance, the place now is a sight to behold. Nice crowd, good (mix of) music, and without the hassle of the centre - recommended.